Autonomous Clinical Infrastructure

Autonomous Medicine for a World in Need.

Certified clinical decisions at machine speed. Physician-verified and fully auditable.

Why now

Healthcare is a distribution problem.

The global physician shortage is structural — 4.3 million doctors short. Training more doctors alone will not close the gap fast enough. Validated clinical workflows, running as infrastructure, can.

Problem framing

Context before mechanism.

Problem

Scale is increasing while clinician time is finite and safety expectations are non-negotiable.

Constraint

Clinical autonomy requires deterministic verification boundaries, not unconstrained AI outputs.

Approach

Certuma's Hybrid Deterministic Architecture combines LLM reasoning with a hard validation layer. Autonomy exists within explicit, auditable boundaries.

Deterministic clinical pathway

From narrative to verified decision.

Clinical inputs are structured, validated through deterministic reasoning, and delivered as auditable, physician-reviewable decisions.

Patient input

dysuriafrequencyurgency24 hoursno flank painno fever

“Burning when I pee since yesterday, going every 20 minutes, no fever, and no back pain.”

Certuma logo

Structured output

Onset: 24 hours
Primary: dysuria
Associated: urgency, frequency
Negative: no fever
Negative: no flank pain
Complication flags: absent

Final diagnosis

Acute uncomplicated cystitis

Confidence: 0.93

Rule criteria matched; no pyelonephritis red flags detected.

Workflow

Safety is not a claim.
It is the product.

Certuma routes every in-scope plan through physician verification. That workflow is the point: fast turnaround without removing accountability.

9:41

Certuma

Patient view

Verified

Today’s check-in

What are you feeling right now?

My throat hurts when I swallow. No trouble breathing. It started two days ago.

sore throat2 daysno dyspneano rash

Risk status

In scope

Next step

Physician review

Plan snapshot

This will appear after sign-off.

Pending

Preview

Hydration + rest

Pain relief per label

Escalate if worse

Activity

Check-in saved

09:14

Safety gates run

09:16

Queued for sign-off

09:19
Intake2m
My throat hurts when I swallow.
Any fever, rash, or trouble breathing?
No rash or breathing issues.
odynophagiano dyspneano rash

01

Conversational intake that becomes a clinical record

Patients describe what is happening in natural language. Certuma continuously structures the details: onset, severity, associated symptoms, negatives, history, medications, allergies, and risk factors.

GatesPass
Emergent red flagsOK
InteractionsOK
Scope limitsOK
Uncertainty thresholdReview

02

Hybrid Deterministic Architecture gates before any plan is drafted

Red flags, contraindications, interaction checks, scope limits, and uncertainty thresholds run through the deterministic verification layer. If something is emergent or out of scope, the system escalates instead of guessing.

ReviewQueue
Sore throat, 48hHold
UTI symptoms, 3dReady
Rash + new medReview
Edit Sign

03

A licensed physician reviews, edits, and signs

Clinicians see structured intake, highlighted risks, and a draft plan with supporting evidence. They approve, edit, or escalate; changes are captured with reason codes and a durable audit trail.

PlanClear
Hydration + rest
Pain relief per label
Escalate if worse
VerifiedShare

04

Patients receive a plan they can act on

Plain language, clear next steps, and a clean summary that can be shared with an existing doctor. The experience avoids ambiguity and “medical word salad.”

Safety

Deterministic Integrity: explicit, auditable, and regulatory-aligned.

Certuma adds a deterministic verification layer to LLM reasoning. Unvalidated paths are rejected. Uncertainty is escalated. Every decision is auditable.

Safety gates

Deterministic checks that run before physician verification and before patient delivery.

Gate
Purpose
Outcome

Emergent red flags

Detect and escalate urgent symptoms

Escalate, do not draft

Contraindications

Screen common exclusions and safety limits

Block unsafe options

Allergies and interactions

Medication conflicts and risk flags

Prevent harmful suggestions

Scope limits

Out-of-scope conditions

Escalate to appropriate care

Uncertainty thresholds

Low-confidence situations

Require clinician review

Provenance capture

Guideline and version tracing

Audit-ready record

Team & Clinical governance

Built by operators, clinicians, and AI engineers.

Our team brings deep experience building and scaling healthcare and technology businesses, combined with clinical, regulatory, and AI engineering.

Martin Varsavsky headshot

Martin Varsavsky

Chief Executive Officer

5x unicorn founder with 30+ years of company-building experience and 10+ years in FDA-regulated medical technology.

  • Founder and chairman of multiple category-defining companies, including Prelude Fertility, the largest IVF network in the United States.
  • Co-founder and chairman of Overture Life, building automation systems for FDA-regulated embryology workflows.
  • Co-founder and chairman of Gameto (FDA IND, Phase 3); board member at Vitara (FDA Breakthrough Device, IDE filed).
  • Previously founded Jazztel, Viatel, and Eolia Renovables, with honors including European Telecommunications Entrepreneur of the Year and Columbia University's Pickering Prize.
Armando Cuesta, MD headshot

Armando Cuesta, MD

Chief Medical Officer

Physician-executive focused on clinical quality, evidence-based pathways, and accountable scale in AI-enabled care delivery.

  • Co-inventor of MedCanon, the deterministic clinical reasoning layer behind Certuma's safety gates and physician verification workflow.
  • Founding Partner at Korion Life Sciences; 15+ years leading scientific diligence and portfolio strategy across biotech, medtech, and genomics (Europe, Israel, U.S.).
  • Co-Founder of Praetorian Bio, developing a first-in-class vaccine approach to prevent dental caries and periodontal disease.
  • Postdoctoral fellowship at Icahn School of Medicine at Mount Sinai in machine learning and translational medicine (peer-reviewed publications; 100+ citations).
  • MD; MBA (Cornell); MS Health Policy and Economics (Weill Cornell). Fellow, New York Academy of Medicine.
Joe Scanlin headshot

Joe Scanlin

Chief Technology Officer

Founder-operator and inventor with deep expertise in physical AI, computational linguistics, and applied medical informatics.

  • Co-inventor of MedCanon, the deterministic clinical reasoning layer that structures narrative intake into auditable, physician-verifiable decision outputs.
  • Founded and exited Scanalytics, an award-winning physical AI company with technology spun out of a U.S. Department of Energy ARPA-E research program.
  • Built the Myome genomic analysis platform (AI-driven interpretation of genetic variants).
  • "Representation Before Retrieval" (a novel approach to integrating structured knowledge into LLM systems).
  • Developed a six-index cognitive-motor function framework (CMFI family) now used in clinical-trial validation of neurological and functional outcomes.
  • Built eli, an AI application using computational linguistics to identify and attenuate mental health deterioration.
Jesus Mejia headshot

Jesus Mejia

Chief Legal Officer

Legal and governance executive focused on cross-border structuring, regulatory risk, and board-level decision quality in complex healthcare and technology environments.

  • 15+ years advising principals, boards, and investment committees on governance design, capital allocation, and long-term risk control.
  • Leads conflict-of-interest and incentive-alignment decisions where governance, regulation, and strategic optionality are tightly linked.
  • Previously served in legal leadership roles at Overture Life, Gameto, Goggo Network, FON, and Jazzya Investments, with investment committee experience at MVB Fund.
  • Background spans venture capital, family investment platforms, and founder-led companies across health, biotech, AI-enabled businesses, and infrastructure-adjacent sectors.
Bruno Marino headshot

Bruno Marino

Head of Digital Products

Product-focused entrepreneur with a track record of scaling high-complexity healthtech and digital commerce operations.

  • Co-Founder and former CEO of Flora Fertilidad (Mexico), an AI-driven reproductive health company where he pioneered patient-centered financing and outcome-based care models powered by proprietary data and intelligent automation.
  • Held senior leadership roles at Vitau (Healthtech/Pharmacy) and VTEX (Enterprise E-commerce), specializing in scaling digital operations and customer success for high-growth, technology-first organizations across the region.
  • Led digital transformation and omnichannel strategy for Farmacity, Argentina's leading pharmacy chain, managing high-scale digital channels in one of the market's most strictly regulated healthcare environments.

Clinicians

Physician oversight at scale — structured, auditable, and efficient.

A review queue designed for speed and clarity: structured intake, highlighted risks and uncertainty, a draft plan with evidence, and a verification UI optimized for edits when needed.

Prioritized queue

Urgency surfaced in plain language; clinicians can approve quickly when appropriate.

Edit-first verification

Modify any element of a plan and capture structured reasons for each change.

Durable audit trail

Immutable logs and encounter provenance support compliance and continuous improvement.

Review queue

A verification surface that keeps the clinician in control.

audit: on
Case
Risk
State

Chest discomfort, intermittent, 6 hours

Structured intake complete; safety gates passed

High attention

Escalate suggested

Urinary symptoms, 3 days

Structured intake complete; safety gates passed

In scope

Ready to review

Rash, new medication started

Structured intake complete; safety gates passed

Drug-related

Review required

Headache with photosensitivity

Structured intake complete; safety gates passed

In scope

Ready to review

Edits captured

Every physician modification is logged with a structured reason so the system remains auditable and improves from verified clinical feedback.

Request access

Get early access to autonomous clinical infrastructure.

 

© 2026 Certuma. All rights reserved.